Positive Life NSW Blog

CROI 2016

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The 23rd annual Conference on Retroviruses and Opportunistic Infections (CROI) recently took place in Boston, Massachusetts 22-25 February 2016. CROI is arguably the world’s most prestigious HIV scientific get-together and the program content is reflective of that ranking.

Image: CROI 2016

If CROI is the world’s most prestigious HIV meeting then NAM’s Aidsmap website www.aidsmap.com is surely in the running for ‘world’s most credible and professional HIV Conference reporting site’.

For summaries and news about individual presentations and research findings, the Aidsmap’s conference bulletins links below provide details with links to additional Aidsmap coverage of the topic, relevant abstract and webcast. Some examples are shown under the Wednesday 2 March heading below.

Wednesday 2 March
Life Expectancy Gap
Despite an overall improvement in life expectancy, US researchers have found that although life expectancy in people with HIV has improved, life expectancy at age 20 remains 13 years behind that of matched HIV-negative people.

Data came from around 25,000 HIV-positive clients of Health Insurer Kaiser Permanente and from ten times that number of HIV-negative clients.

Improving the Care Cascade in African countries
A number of studies reported on innovative approaches to improving the care cascade and increasing momentum towards achieving 90/90/90 goals (90% of HIV positive people diagnosed and on treatment with undetectable viral loads).

The search for a cure – TLR7 agonist Researchers working on a functional cure for HIV presented further data on GS-9620, an investigational toll-like receptor or TLR7 agonist, in an early animal study. Toll-like receptors on immune cells are part of the innate or immediate immune response, but they promote adaptive immunity, or recognition of and response to specific viruses and other pathogens. TLR7 activation leads to increased antigen presentation and enhanced activity of natural killer cells, antibody-producing B-cells, and CD4 and CD8 T-cells.

Eleven rhesus macaques infected with a simian relative of HIV and already virally suppressed through use of conventional ART were then also treated with low doses of TLR7 agonists. ART was then stopped and two of the monkeys maintained viral suppression for at least three months. This suggests that there is promise in this approach which aims to develop a therapy which can stimulate the body to drive latent HIV out of viral reservoirs in infected cells and to enhance virus-specific immune responses in humans living with HIV.


The links below give full access to Aidsmap’s coverage of CROI 2016, commencing with a Conference News and Highlights overview.

The full list of Abstracts and Conference Program is also available at the CROI2016 website.

Conference Bulletins

The following link directly to conference bulletins for that date.

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